Idiosyncratic DILI (iDILI) is a rare and unpredictable event that is responsible for drug removal from the market. Prediction of iDILI occurrence at early phase of drug development is extremely challenging.
PredictCan Biotechnologies uses a state-of-the-art 3D individual-centric model that contains hepatocytes, hepatic stellate cells, macrophages, and dendritic cells to accurately detect immune-mediated and non-immune-mediated iDILI.
Our technology allows us to generate cohorts of individuals and to identify which subject is at risk for iDILI occurrence when exposed to a given drug, and also to gain host factor-associated toxicology insights including age and sex.
Prediction of iDILI risk induced by troglitazone and its non-DILI partner rosiglitazone on a cohort of individuals
No iDILI detected with rosiglitazone.
iDILI risk detected with troglitazone in 5 individuals:
Female, 46-year-old / Female, 31-year-old / Female, 31-year-old / Male, 37-year-old / Male, 44-year-old
Prediction of immune-mediated iDILI risk induced by diclofenac and its non-DILI partner acetylsalicylic acid (ASA) on a cohort of individuals
No iDILI detected with acetylsalicylic acid.
Immune-mediated iDILI detected with diclofenac in a 45-year-old male.